The sequences bioinformatic analysis results of the of the bovine immunodeficiency virus main genes (gag, env, pol), and updated data on the phylogenetic relationships of the pathogen are presented in the article. The existence of at least two genetic groups of BIV, which have a common origin from a common ancestor, has been established. In addition, the complexity of conducting a full-fledged and comprehensive sequence analysis for a complete understanding of the evolution and virus phylogenetic relationships was noted. It was determined that the lack of a single methodological approach to BIV sequencing in different world scientific communities complicates the analysis and interpretation of the obtained data. The application of whole-genome sequencing technologies is proposed to solve this issue
Keywords: phylogenetic relationships, Lentivirus, Retroviridae
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