The obtained experimental-analytical data indicate a significant risk of occurrence of circovirus-associated syndrome complexes proliferative necrotic pneumonia and a complex of respiratory diseases of pigs (PNP and PRDC) from the presence of Pasteurella and Pasteurellacea bacteria in barley grain (OR = 3.48; 2.21 < OR < 5.50; p ≤ 0.01 at n = 633) and the critical importance of these bacteria for the clinical manifestation of these syndromes in pig farms of Ukraine, which are seropositive both for PCV-2 and AD (OR = 35.45; 18.12 < OR < 69.35; p ≤ 0.001 at n = 433). Thus, barley grain grown on forage lands “fertilized” with pig manure is a factor in the transmission of at least pasteurellae in the epizootic chains of PNP and PRDC, and thus form a “feed chain” of PCV-2. Prospects for further development of the concept of the food chain of circovirus-associated infections in pig breeding are discussed
Keywords: Aujeszky disease virus, pasteurellae, barley
Dee S. A., Bauermann F. V., Niederwerder M. C., Singrey A., Clement T., de Lima M., Long C., Patterson G., Sheahan M. A., Stoian A. M. M., Petrovan V., Jones C. K., De Jong J., Ji J., Spronk G. D., Minion L., Christopher-Hennings J., Zimmerman J. J., Rowland R. R. R., Nelson E., Sundberg P., Diel D. G. Survival of viral pathogens in animal feed ingredients under transboundary shipping models. PloS One. 2018. Vol. 13, iss. 3. P. e0194509. DOI: https://doi.org/10.1371/journal.pone.0194509.
New Zealand Government. Biosecurity (Meat and Food Waste for Pigs) Regulations 2005 (SR 2005/150). Wellington, 7 June 2005. URL: https://www.legislation.govt.nz/regulation/public/2005/0150/latest/096be8ed81296cad.pdf.
European Council. Council directive of 12 December 1991 concerning the protection of waters against pollution caused by nitrates from agricultural sources (91/676/EEC). Official Journal of the European Union. 1991. Vol. L 375. P. 1–8. URL: http://data.europa.eu/eli/dir/1991/676/oj.
Zijstra R., Beltranena E. Barley in swine diets. In: McAllister T., Meale S., eds. Barley Grain Feed Industry Guide. Calgary : Alberta Barley, 2015. P. 22–24. URL: https://www1.agric.gov.ab.ca/$Department/deptdocs.nsf/all/lr14779/$FILE/barleyfeedguide-swinediets.pdf.
Schijven J., Derx J., de Roda Husman A. M., Blaschke A. P., Farnleitner A. H. QMRAcatch: microbial quality simulation of water resources including infection risk assessment. Journal of Environmental Quality. 2015. Vol. 44, iss. 5. P. 1491–1502. DOI: https://doi.org/10.2134/jeq2015.01.0048.
Demeter K., Derx J., Komma J., Parajka J., Schijven J., Sommer R., Cervero-Aragó S., Lindner G., Zoufal-Hruza C. M., Linke R., Savio D., Ixenmaier S. K., Kirschner A. K. T., Kromp H., Blaschke A. P., Farnleitner A. H. Modelling the interplay of future changes and wastewater management measures on the microbiological river water quality considering safe drinking water production. The Science of the Total Environment. 2021. Vol. 768. P. 144278. DOI: https://doi.org/10.1016/j.scitotenv.2020.144278.
Segalés J. Porcine circovirus type 2 (PCV2) infections: clinical signs, pathology and laboratory diagnosis. Virus Research. 2012. Vol. 164, iss. 1–2. P. 10–19. DOI: https://doi.org/10.1016/j.virusres.2011.10.007.
Ребенко Г. І. Етіологія та епізоотологія інфекційних хвороб респіраторного тракту свиней (огляд літератури). Вісник Сумського національного аграрного університету. Серія : Ветеринарна медицина. 2014. Вип. 1. С. 114–121. URL: http://nbuv.gov.ua/UJRN/Vsna_vet_2014_1_34.
Ситюк М. П., Байдалюк В. А., Ничик С. А., Розумнюк А. В., Галка І. В., Шапошнік В. М., Фурда І. Л. Цирковірусні інфекції. Київ : Аграрна наука, 2017. 128 с. ISBN: 9789665404576.
Yu X., Sun Q., Ku X., He D., Li Z., Ghonaim A. H., Fan S., He Q. The epidemiological investigation of co-infection of major respiratory bacteria with pseudorabies virus in intensive pig farms in China. Veterinary Medicine and Science. 2021. Vol. 7, iss. 1. P. 175–183. DOI: https://doi.org/10.1002/vms3.289.
Kolchyk O. V., Buzun A. I., Paliy A. P., Nalivayko L. I., Chekan O. M., Grebenik N. P., Bondarenko I. V., Rebenko H. I., Kushnir V. Yu., Todorov N. I. Biofilms of pathogenic bacteria in pig industry. Ukrainian Journal of Ecology. 2020. Vol. 10, iss. 4. P. 202–209. DOI: https://doi.org/10.15421/2020_189.
Неволько О. М., Ситюк М. П. Результати серологічних моніторингових досліджень щодо цирковірусної інфекції серед свійських свиней на території України за період 2010–2014 рр. Науковий вісник ветеринарної медицини : зб. наук. праць. 2013. Вип. 12. С. 40–45. URL: http://nbuv.gov.ua/UJRN/nvvm_2013_12_0.
Ситюк М. П. Показники рівня постінфекційних нейтралізуючих антитіл проти цирковірусу свиней другого типу у сироватках крові диких свиней. Ветеринарна медицина : міжвід. темат. наук. зб. 2014. Вип. 98. С. 68–71. URL: http://nbuv.gov.ua/UJRN/vetmed_2014_98_19.
Прохорятова О. В., Корнєйков О. М., Кольчик О. В., Ісаков М. М. Визначення основних причин поширення інфекційних пневмоентеритів великої рогатої худоби в сучасних умовах. Ветеринарна медицина : міжвід. темат. наук. зб. 2017. Вип. 103. С. 209–213. URL: http://www.jvm.kharkov.ua/sbornik/103/3_47.pdf.
López-Soria S., Maldonado J., Riera P., Nofrarías M., Espinal A., Valero O., Blanchard P., Jestin A., Casal J., Domingo M., Artigas C., Segalés J. Selected swine viral pathogens in indoor pigs in Spain. Seroprevalence and farm-level characteristics. Transboundary and Emerging Diseases. 2010. Vol. 57, iss. 3. P. 171–179. DOI: https://doi.org/10.1111/j.1865-1682.2010.01135.x.
Chen N., Huang Y., Ye M., Li S., Xiao Y., Cui B., Zhu J. Co-infection status of classical swine fever virus (CSFV), porcine reproductive and respiratory syndrome virus (PRRSV) and porcine circoviruses (PCV2 and PCV3) in eight regions of China from 2016 to 2018. Infection, Genetics and Evolution. 2019. Vol. 68. P. 127–135. DOI: https://doi.org/10.1016/j.meegid.2018.12.011.
Allan G. M., Ellis J. A. Porcine circoviruses: a review. Journal of Veterinary Diagnostic Investigation. 2000. Vol. 12, iss. 1. P. 3–14. DOI: https://doi.org/10.1177/104063870001200102.
Banda A., Galloway-Haskins R. I., Sandhu T. S., Schat K. A. Genetic analysis of a duck circovirus detected in commercial Pekin ducks in New York. Avian Diseases. 2007. Vol. 51, iss. 1. P. 90–95. DOI: https://doi.org/10.1637/0005-2086(2007)051[0090:GAOADC]2.0.CO;2.
Blinkova O., Victoria J., Li Y., Keele B. F., Sanz C., Ndjango J. B., Peeters M., Travis D., Lonsdorf E. V., Wilson M. L., Pusey A. E., Hahn B. H., Delwart E. L. Novel circular DNA viruses in stool samples of wild-living chimpanzees. The Journal of General Virology. 2010. Vol. 91, iss. 1. P. 74–86. DOI: https://doi.org/10.1099/vir.0.015446-0.
Lőrincz M., Cságola A., Farkas S. L., Székely C., Tuboly T. First detection and analysis of a fish circovirus. The Journal of General Virology. 2011. Vol. 92, iss. 8. P. 1817–1821. DOI: https://doi.org/10.1099/vir.0.031344-0.
Todd D. Circoviruses: immunosuppressive threats to avian species: a review. Avian Pathology. 2000. Vol. 29, iss. 5. P. 373–394. DOI: https://doi.org/10.1080/030794500750047126.
Kim K. S., Fulton R. W. Ultrastructure of Datura stramonium infected with a Euphorbia virus suggestive of a whitefly-transmitted virus. Phytopathology. 1984. Vol. 74, iss. 2. P. 236–241. DOI: https://doi.org/10.1094/Phyto-74-236.
Rojas M. R., Hagen C., Lucas W. J., Gilbertson R. L. Exploiting chinks in the plant’s armor: evolution and emergence of geminiviruses. Annual Review of Phytopathology. 2005. Vol. 43. P. 361–394. DOI: https://doi.org/10.1146/annurev.phyto.43.040204.135939.
Briddon R. W., Patil B. L., Bagewadi B., Nawaz-ul-Rehman M. S., Fauquet C. M. Distinct evolutionary histories of the DNA-A and DNA-B components of bipartite begomoviruses. BMC Evolutionary Biology. 2010. Vol. 10. P. 97. DOI: https://doi.org/10.1186/1471-2148-10-97.
Rosario K., Marinov M., Stainton D., Kraberger S., Wiltshire E. J., Collings D. A., Walters M., Martin D. P., Breitbart M., Varsani A. Dragonfly cyclovirus, a novel single-stranded DNA virus discovered in dragonflies (Odonata: Anisoptera). The Journal of General Virology. 2011. Vol. 92, iss. 6. P. 1302–1308. DOI: https://doi.org/10.1099/vir.0.030338-0.
Tiendrébéogo F., Lefeuvre P., Hoareau M., Harimalala M. A., De Bruyn A., Villemot J., Traoré V. S., Konaté G., Traoré A. S., Barro N., Reynaud B., Traoré O., Lett J. M. Evolution of African cassava mosaic virus by recombination between bipartite and monopartite begomoviruses. Virology Journal. 2012. Vol. 9. P. 67. DOI: https://doi.org/10.1186/1743-422X-9-67.
Padilla-Rodriguez M. Detection of single-stranded DNA viruses in insects and wild vegetation : thesis submitted in partial fulfillment of the requirements of the University Honors Program. Saint Petersburg : University of South Florida, 2012. 22 pp. URL: https://digitalcommons.usf.edu/honorstheses/113.
Jestin A., Clement G., eds, Proceedings of the symposium on ssDNA viruses of plants, birds, pigs and primates (Saint-Malo, France, 24–27 September 2001). Ploufragan : Zoo Pole, 2001. 147 pp.
Boevink P. Ch. Surin B. P., Keese P. K., Chu P. W. G., Waterhouse P. M., Khan R. I., Larkin Ph. J., Taylor W. C., Marshall J. S. Plant transcription regulators from circovirus : patent WO1996006932A1 WIPO. International application No. PCT/AU1995/000552 ; international filing date 30.08.95 ; publication date 07.03.96. 121 pp. URL: https://patentscope.wipo.int/search/en/detail.jsf?docId=WO1996006932.
Wilhelm S. W., Suttle C. A. Viruses and nutrient cycles in the sea: viruses play critical roles in the structure and function of aquatic food webs. BioScience. 1999. Vol. 49, iss. 10. P. 781–788. DOI: https://doi.org/10.2307/1313569.
Tischer I., Rasch R., Tochtermann G. Characterization of papovavirus-and picornavirus-like particles in permanent pig kidney cell lines. Zentralblatt fur Bakteriologie, Parasitenkunde, Infektionskrankheiten und Hygiene. Erste Abteilung Originale. Reihe A: Medizinische Mikrobiologie und Parasitologie. 1974. Bd. 226, Hf. 2. S. 153–167. PMID: https://pubmed.ncbi.nlm.nih.gov/4151202.
Tischer I., Gelderblom H., Vettermann W., Koch M. A. A very small porcine virus with circular single-stranded DNA. Nature. 1982. Vol. 295, iss. 5844. P. 64–66. DOI: https://doi.org/10.1038/295064a0.
Tischer I., Mields W., Wolff D., Vagt M., Griem W. Studies on epidemiology and pathogenicity of porcine circovirus. Archives of Virology. 1986. Vol. 91, iss. 3–4. P. 271–276. DOI: https://doi.org/10.1007/BF01314286.
Tischer I., Peters D., Rasch R., Pociuli S. Replication of porcine circovirus: induction by glucosamine and cell cycle dependence. Archives of Virology. 1987. Vol. 96, iss. 1–2. P. 39–57. DOI: https://doi.org/10.1007/BF01310989.
Dulac G. C., Afshar A. Porcine circovirus antigens in PK-15 cell line (ATCC CCL-33) and evidence of antibodies to circovirus in Canadian pigs. Canadian Journal of Veterinary Research. 1989. Vol. 53, iss. 4. P. 431–433. PMCID: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1255571.
Edwards S., Sands J. J. Evidence of circovirus infection in British pigs. The Veterinary Record. 1994. Vol. 134, iss. 26. P. 680–681. DOI: https://doi.org/10.1136/vr.134.26.680.
LeCann P., Albina E., Madec F., Cariolet R., Jestin A. Piglet wasting disease. The Veterinary Record. 1997. Vol. 141, iss. 25. P. 660. PMID: https://pubmed.ncbi.nlm.nih.gov/9466392.
Ellis J., Hassard L., Clark E., Harding J., Allan G., Willson P., Strokappe J., Martin K., McNeilly F., Meehan B., Todd D., Haines D. Isolation of circovirus from lesions of pigs with postweaning multisystemic wasting syndrome. The Canadian Veterinary Journal. 1998. Vol. 39, iss. 1. P. 44–51. PMCID: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1539838.
Segalés J., Allan G. M., Domingo M. Porcine circovirus diseases. Animal Health Research Reviews. 2005. Vol. 6, iss. 2. P. 119–142. DOI: https://doi.org/10.1079/ahr2005106.